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KMID : 0616120180490010065
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 1 p.65 ~ p.69
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Optimization of Extraction Conditions of Torilin, a Melanogenesis Inhibitor from Torilis japonica Fruits
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Jo Yang-Hee
Ahn Jong-Hoon
Song Da-Hye
Hwang Bang-Yeon
Lee Mi-Kyeong
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Abstract
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Torilin is a major sesquiterpene of Torilis japonica (Umbelliferae) fruits and known to be a melanogenesis inhibitor. Extraction conditions are important factor for the efficient preparation to save cost and time in economic aspects. For this reason, this study was conducted to optimize the extraction condition for maximal yield of torilin. For optimization, extraction factors such as extraction solvent, extraction temperature and sample/solvent ratio were tested and optimized for maximum yield of torilin using response surface methodology with Box-Behnken design (BBD). The optimal condition was obtained as a EtOAc concentration in MeOH of 31.8%, an extraction temperature at 30.3oC and a sample/solvent ratio, 1000 mg/2 ml. The torilin yield under optimal conditions was found to be 9.9 mg/g dried samples, which were well-matched with the predicted value of 10.4 mg/g dried samples. These results will provide useful information about optimized extraction conditions for the development of torilin as cosmetic therapeutics to reduce skin hyperpigmentation.
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KEYWORD
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Torilin, Torilis japonica, Optimization, Response surface methodology, Melanogenesis inhibitor
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